Combining heterogeneously labeled datasets for training segmentation networks

Abstract

Accurate segmentation of medical images is an important step towards analyzing and tracking disease related morphological alterations in the anatomy. Convolutional neural networks (CNNs) have recently emerged as a powerful tool for many segmentation tasks in medical imaging. The performance of CNNs strongly depends on the size of the training data and combining data from different sources is an effective strategy for obtaining larger training datasets. However, this is often challenged by heterogeneous labeling of the datasets. For instance, one of the dataset may be missing labels or a number of labels may have been combined into a super label. In this work we propose a cost function which allows integration of multiple datasets with heterogeneous label subsets into a joint training. We evaluated the performance of this strategy on thigh MR and a cardiac MR datasets in which we artificially merged labels for half of the data. We found the proposed cost function substantially outperforms a naive masking approach, obtaining results very close to using the full annotations.