Arborcandins A, B, C, D, E and F, novel 1,3-β-glucan synthase inhibitors: Physico-chemical properties and structure elucidation

Abstract

Arborcandins A, B, C, D, E and F, which possess potent 1,3-β-glucan synthase inhibitory activity, were isolated from the cultured broth of a filamentous fungus, strain SANK 17397. The structures of arborcandins A, B, C, D, E and F were elucidated by a combination of NMR and mass spectrometry, and established to be novel cyclic peptides containing uncommon amino acid residues.