Molecular biology of leukemias

Abstract

Normal hematopoiesis is a meticulously controlled process of cell division and differentiation arising from hematopoietic stem cells with self-renewal capacity. This process is regulated through several signaling pathways that appear to be, to some degree, redundant. In many neoplastic processes, alteration of one or several signaling pathways has been observed, implicating these pathways in pathogenesis.