Driving glioblastoma growth by alternative polyadenylation

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Abstract

Global shortening of 3' untranslated regions (3' UTRs) through alternative polyadenylation is an emerging hallmark of cancer. A recent study identifies the cleavage factor Im 25 (CFIm25) as an important mediator of 3' UTR shortening in glioblastomas and demonstrates a causal relationship between alternative polyadenylation and cancer cell proliferation.

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Han, T., & Kim, J. K. (2014, September 1). Driving glioblastoma growth by alternative polyadenylation. Cell Research. https://doi.org/10.1038/cr.2014.88

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