Non-islet cell tumor hypoglycemia is caused by big IGF-II in a patient with a carcinosarcoma of the uterus

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Abstract

We report a 72-year-old Japanese woman with severe hypoglycemia. The laboratory data, which revealed the suppression of serum insulin, suggested the existence of non-islet cell tumor hypoglycemia (NICTH). Abdominal computed tomography demonstrated the presence of a huge uterine tumor. The patient was treated with a continuous infusion of glucose, but died of sepsis on day 46. An autopsy revealed the pathological diagnosis to be a carcinosarcoma of the uterus. Interestingly, an immunohistochemical study discovered the expression of insulin-like growth factor (IGF)-II in both the carcinoma and sarcoma cells. In addition, an immunoblot analysis of blood samples revealed the presence of circulating big IGF-II. Therefore, this is a novel case of NICTH that was caused by a uterine carcinosarcoma.

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Honma, H., Takahashi, Y., Matsui, M., Satoh, T., Fukuda, I., Takahashi, K., … Ishigaki, Y. (2015). Non-islet cell tumor hypoglycemia is caused by big IGF-II in a patient with a carcinosarcoma of the uterus. Internal Medicine, 54(24), 3165–3169. https://doi.org/10.2169/internalmedicine.54.4945

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