The Effect of the Ethanolic Extract of Asam Jawa Leaf (Tamarindus Indica L.) in Total Cholesterol, Triglyceride, LDL and HDL Concentration on Male Sprague Dawley Rats

Abstract

The objective of this study is to investigate the effect of ethanolic extract of Tamarindus indica L. in total cholesterol, LDL, triglyceride, and HDL level. The rats were grouped into 6 groups: namely normal control, negative, positive, and the test group that divided into doses I (1.748 mg / 200 g BW), dose II(3.497 mg / 200 grams BW) and dose III (6.994 mg / 200 grams BW). The rats come by switched from commercial food to an egg yolk and induced by propylthiouracil for 10 days (exception normal control group). The test compounds are administered one hour after induction for 10 days. The blood was taken in days of 11. The method to determine lipid fractions using Enzymatic Photometric Test. The results of this study showed that three doses of ethanolic extract of tamarind leaves can decrease the total cholesterol, LDL, and increase HDL levels. The percentage of cholesterol total decreasing were 16.70% (test dose I), 18.05% (test dose II), 19.18% (test dose III), LDL decreasing were 31.94% (test dose I), 61.05% (test dose II), 65.19% (test dose III ) and the percentage of HDL increasing were, 17.73% (test dose I) 79.10% (test dose II) 84.76% (test dose III). All the test dose showed significant (p<0.05) than the negative group. The obtained results revealed that ethanolic extract of Tamarindus indica exhibited significant effect (p<0.05) of lowering concentration of total cholesterol, LDL, triglyceride, and the increase of HDL concentration.