Trichothecenes production by the Hypocrealean epibiont of Baccharis coridifolia

Abstract

The Hypocrealean epibiont of Baccharis coridifolia has been shown to synthesize de novo a series of macrocyclic trichothecene antibiotics, such as roridin A, roridin E, verrucarin A and verrucarin J. The structures of the compounds were determined by spectroscopic methods (1H- and 13C-NMR and FABMS).