CHA2DS2-VASc score predicts contrast-induced nephropathy in patients with ST-segment elevation myocardial infarction, who have undergone primary percutaneous coronary intervention

Abstract

Background and aim: We aimed to investigate the predictive value of the CHA2DS2-VASc score in the development of contrast-induced nephropathy (CIN). Methods: A total of 2972 patients who had been diagnosed with ST elevation myocardial infarction (STEMI) and who had undergone primary coronary angioplasty were included in the study. The patients were divided into three groups according to the CHA2DS2-VASc score, i.e.: low risk (1 point), intermediate risk (2 points), and high risk (≥ 3 points). The groups were followed with regard to CIN development. Results: The median CHA2DS2-VASc score was significantly higher in the CIN(+) group compared to the CIN(–) group (3 vs. 2, p < 0.001). The rate of CIN was 3.32-fold higher (OR 3.32, 95% CI 1.98–5.55, p < 0.001) in the high-risk group (CHA2DS2-VASc ≥ 3) compared to the low-risk group (CHA2DS2-VASc = 1). Age (OR 1.25, 95% CI 1.14–1.36, p < 0.001), female gender (OR 1.52, 95% CI 1.23–1.89, p < 0.001), hypertension (OR 1.50, 95% CI 1.265–1.78, p < 0.001), peak creatinine kinase-MB (OR 1.15, 95% CI 1.10–1.21, p < 0.001), and the Killip score > 1 (OR 4.25, 95% CI 3.10–5.82, p < 0.001) were found to be independent predictors for CIN development. Conclusions: The CHA2DS2-VASc score is an independent and strong predictor of CIN development in patients with acute STEMI.