Solubility enhancement and evaluation of Cilnidipine using solid Dispersion techniques

Abstract

The poor solubility of Cilnidipine leads to low bioavailability and limits its therapeutic efficacy. To develop a dosage form that is stable, effective and has a higher bioavailability. It is necessary to increase the solubility of such medications. The present study aimed to improve the solubility by solid dispersion technique of Cilnidipine by solid dispersion techniques. Solvent evaporation and melt fusion methods were used to prepare solid dispersions of the drug cilnidipine with various polymers. The solubility of these prepared solid dispersions was evaluated by FT-IR spectroscopy, Differential Scanning Colorimetry and X-ray diffraction. The greatest solubility, of 21.07 µg/mL, was found in the solid dispersion that was developed by solvent evaporation technique employing a combination of Cilnidipine and Poloxamer 188 in a 1:9 ratio. The current investigation showed that solid dispersion using Poloxamer 188 can be a potentially effective method to increase the solubility and rate of dissolution of cilnidipine.