Tropism of PCNSL: Is it all about autoantigens?

Abstract

In this issue of Blood, Thurner et al identified that two-thirds of patients with primary central nervous system lymphoma (PCNSL) have B-cell receptors (BCRs) specific for 2 autoantigens, SAMD14 and neurabin-1. These antigens are predominantly expressed in the central nervous system (CNS), induced strong BCR pathway activation, and autorecognition of them is therefore an attractive explanation for the CNS tropism of the disease.