Animal models in functional magnetic resonance imaging

Abstract

Functional magnetic resonance imaging (fMRI) has significantly advanced brain research, both in basic sciences as well as in translational and clinical studies. Animal models have been at the forefront of research into the mechanisms of magnetic resonance imaging (MRI) and fMRI. The use of animal models in fMRI has been particularly advantageous in preclinical and translational studies of various models of brain disease, and fundamental in the exploration of basic neuroscience questions, such as the mechanisms of perception, behavior, and cognition. This chapter describes the practical aspects of the use of animal models in fMRI studies of the brain. © 2008 Humana Press Inc.