Expression Profile of Aging and Oxidative Stress Response in Drosophila melanogaster

Abstract

The free radical hypothesis of aging suggests that reactive oxygen species accumulated with age cause oxidative damages to molecules, such as nucleic acids, proteins and lipids, and are causally linked to aging and death(1). The regulation of gene expression in aging and its correlation with that in response to oxidative stress, however, is poorly understood. We have used the microarray technique to study the genome-wide expression patterns of aging and oxidative stress response in Drosophila melanogaster.