The chemical probe–scopes, limitations and challenges

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Abstract

Drug design needs high-quality chemical probes for target validation, but the demands on chemical probes are largely different than those on drugs. Whereas therapeutic value and safety are main criteria for a drug evaluation, the chemical probe is influencing a biological target in a well-characterized way. Affinity, efficacy, selectivity and versatility in different read-outs are main criteria for chemical probes to test biochemical hypothesis and verify targets for new therapeutic approaches.

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Stark, H. (2020, December 1). The chemical probe–scopes, limitations and challenges. Expert Opinion on Drug Discovery. Taylor and Francis Ltd. https://doi.org/10.1080/17460441.2020.1781086

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