Drug design needs high-quality chemical probes for target validation, but the demands on chemical probes are largely different than those on drugs. Whereas therapeutic value and safety are main criteria for a drug evaluation, the chemical probe is influencing a biological target in a well-characterized way. Affinity, efficacy, selectivity and versatility in different read-outs are main criteria for chemical probes to test biochemical hypothesis and verify targets for new therapeutic approaches.
CITATION STYLE
Stark, H. (2020, December 1). The chemical probe–scopes, limitations and challenges. Expert Opinion on Drug Discovery. Taylor and Francis Ltd. https://doi.org/10.1080/17460441.2020.1781086
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