Novel method for rapid, simultaneous T1, T2*, and proton density quantification

Abstract

An imaging method called "quantification of relaxation times and proton density by twin-echo saturation-recovery turbo-field echo" (QRAPTEST) is presented as a means of quickly determining the longitudinal T1 and transverse T2* relaxation time and proton density (PD) within a single sequence. The method also includes an estimation of the B1 field inhomogeneity. High-resolution images covering large volumes can be achieved within clinically acceptable times of 5-10 min. The range of accuracy for determining T1, T2*, and PD values is flexible and can be optimized relative to any anticipated values. We validated the experimental results against existing methods, and provide a clinical example in which quantification of the whole brain using 1.5 mm 3 voxels was achieved in less than 8 min. © 2007 Wiley-Liss, Inc.