Silver acetylides and organic azides react under copper(i) catalysis to afford 1,4-disubstituted 1,2,3-triazoles. Mechanistic studies implicate a process involving transmetallation to copper acetylides prior to cycloaddition. This work demonstrates that silver acetylides serve as suitable precursors for entry into copper-mediated coupling reactions. This methodology allows the incorporation of volatile and difficult-to-handle acetylenes into the triazole core. © 2011 The Royal Society of Chemistry.
CITATION STYLE
Proietti Silvestri, I., Andemarian, F., Khairallah, G. N., Wan Yap, S., Quach, T., Tsegay, S., … Williams, S. J. (2011). Copper(i)-catalyzed cycloaddition of silver acetylides and azides: Incorporation of volatile acetylenes into the triazole core. Organic and Biomolecular Chemistry, 9(17), 6082–6088. https://doi.org/10.1039/c1ob05360d
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