Age-related changes in β-adrenergic neuroeffector systems in the human heart

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Abstract

Background. Aging decreases cardiac β-adrenergic responsiveness in model systems and in humans in vivo. The purpose of this study was to comprehensively evaluate the age-related changes in the β-receptor-G protein-adenylyl cyclase complex in nonfailing human hearts. Methods and Results. Twenty-six nonfailing explanted human hearts aged 1 to 71 years were obtained from organ donors and subjected to pharmacological investigation of β-adrenergic neuroeffector systems. When the population was subdivided into the 13 youngest and 13 oldest subjects, total β-receptor density assessed by maximum [125I]ICYP binding (β(max)) was reduced in older hearts by 37% in left ventricles and 31% in right ventricles (both P

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White, M., Roden, R., Minobe, W., Khan, M. F., Larrabee, P., Wollmering, M., … Bristow, M. R. (1994). Age-related changes in β-adrenergic neuroeffector systems in the human heart. Circulation, 90(3), 1225–1238. https://doi.org/10.1161/01.CIR.90.3.1225

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