Gene polymorphisms of novel immunotolerant molecule BTLA: Distribution of alleles, genotypes and haplotypes in polish Caucasian population

9Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

B and T lymphocyte attenuator (BTLA) is one of the members of immunoglobulin superfamily which, like CTLA-4 and PD-1, is involved in down regulation of immune response. Despite the important role of BTLA in maintaining immune homeostasis, relatively little studies were devoted to the relationship of polymorphisms in the gene encoding BTLA with susceptibility to autoimmune disease and cancer. Moreover, all published works were done in Asian populations. BTLA gene is located on chromosome 3 in q13.2 and consists of five exons. The aim of this study was to investigate the alleles, genotypes and haplotypes frequency of selected BTLA gene polymorphisms in Caucasian population originating from Poland. For this study, the single-nucleotide polymorphisms (SNPs) were chosen on the basis of literature data. Additionally, the tag dSNP under linkage equilibrium r2>0.8 and available at the National Center for Biotechnology Information (NCBI) for Caucasian population of rare alleles at a frequency greater than 5 % have been chosen using the NCBI database. The ten BTLA SNPs investigated were: rs1844089, rs2705535, rs9288952, rs9288953, rs1982809, rs2633580, rs2705511, rs2705565, rs76844316, rs16859633. For all SNPs selected on the basis of literature data the significantly different distributions of genotypes between Asian and Caucasian populations were observed.

Cite

CITATION STYLE

APA

Partyka, A., Woszczyk, D., Strzała, T., Szczepańska, A., Tomkiewicz, A., Frydecka, I., & Karabon, L. (2014). Gene polymorphisms of novel immunotolerant molecule BTLA: Distribution of alleles, genotypes and haplotypes in polish Caucasian population. Archivum Immunologiae et Therapiae Experimentalis, 63(1), 73–78. https://doi.org/10.1007/s00005-014-0300-3

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free