Synthesis of some pyrazole containing chalcones and pyridine-3-carbonitriles and study of their anti-inflammatory activity

Abstract

In present work the 4-formyl pyrazole (1) were treated with 4-morpholinoacetophene (2) in the presence of aqueous KOH to give Chalcones (3). The chalcones are subjected to react with malononitrile using sodium methoxide as a base in methanol to give pyridine-3-carbonitriles (4). The synthesized chalcone and pyridine-3-carbonitrile derivatives were subjected for study of their anti-inflammatory activity by the well known carrageenan induced rat paw edema method. The products 3a, 3e and 4e exhibited good activity as compared with standard diclofenac drug. The formation of all compounds was established by the spectral techniques such as Infra Red, 1H-NMR and mass.