The emergence of multi-drug resistant strains of Plasmodium falciparum has rendered many affordable antimalarials, such as chloroquine, much less effective in addressing the severe health issues in sub-Saharan Africa, Southeast Asia and the Amazon region. In order to overcome the neurotoxicity of an initial series of artemisinin-derived drugs and their relatively high production costs, an intensive and all-inclusive research programme to develop new derivatives has been undertaken. Two efficient antimalarial drug candidates of different chemotype have been devised, the artemisinin derivative artemisone and 1,2,4-troxolane OZ277. Both are nontoxic, more potent than artemisinin and should be affordable to people of endemic regions. The same may hold for the backup candidates artemiside and OZ439.
CITATION STYLE
Opsenica, D. M., & Šolaja, B. A. (2012). Second-generation peroxides: The OZs and artemisone. In Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use (pp. 191–211). Humana Press Inc. https://doi.org/10.1007/978-3-0346-0480-2_10
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