Monoclonal antibody therapy for non-malignant disease

Abstract

Advances in technology have enabled monoclonal antibodies to be produced which bind to specific antigens associated with disease processes. By targeting these antigens the antibodies can destroy or alter the function of cells which express the target. They may also bind and thereby inhibit pro-inflammatory cytokines such as tumour necrosis factor. In addition to cancer treatment, monoclonal antibodies may be useful in diseases with an immune component such as rheumatoid arthritis and psoriasis. Monoclonal antibodies can have serious adverse reactions such as severe allergy and infection.