MicroRNA-associated therapies

Abstract

The micro(mi)RNA pathway play crucial roles in the regulation of our genome and is implicated in fundamental aspects of our physiology. Therefore, deregulations of miRNA expression are often associated with human malignancies including cancers, neuronal diseases or viral infections. They can even be considered as excellent diagnostic or prognostic markers. Several biotechnological tools are now available to measure miRNA expression in patient samples and to reproduce or inhibit the miRNA action on translation repression. We present here these different miRNA-based techniques and discuss their potential applications in the clinical management of several human diseases.