The main goal of this work was to assess the accuracy of several well-known methods which provide global (BSI and SIENA) or local (Jacobian integration) estimates of longitudinal atrophy in brain structures using Magnetic Resonance images. For that purpose, we have generated realistic simulated images which mimic the patterns of change obtained from a cohort of 19 real controls and 27 probable Alzheimer's disease patients. SIENA and BSI results correlate very well with gold standard data (BSI mean absolute error < 0.29%; SIENA < 0.44%). Jacobian integration was guided by both fluid and FFD-based registration techniques and resulting deformation fields and associated Jacobians were compared, region by region, with gold standard ones. The FFD registration technique provided more satisfactory results than the fluid one. Mean absolute error differences between volume changes given by the FFD-based technique and the gold standard were: sulcal CSF < 2.49%; lateral ventricles < 2.25%; brain < 0.36%; hippocampi < 1.42%. © Springer-Verlag Berlin Heidelberg 2007.
CITATION STYLE
Camara, O., Scahill, R. I., Schnabel, J. A., Crum, W. R., Ridgway, G. R., Hill, D. L. G., & Fox, N. C. (2007). Accuracy assessment of global and local atrophy measurement techniques with realistic simulated longitudinal data. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 4792 LNCS, pp. 785–792). Springer Verlag. https://doi.org/10.1007/978-3-540-75759-7_95
Mendeley helps you to discover research relevant for your work.