Effect of Indigestible Dextrin on Cholesterol Metabolism in Rat.

Abstract

Using an indigestible dextrin (PF: 58.2% dietary fiber and PF-C: 91.6% dietary fiber as determined by HPLC) obtained through pyrolysis of potato starch, its effects on cholesterol metabolism in rats were evaluated. The results are summarized as follows: 1) The levels of serum cholesterol and trigIyceride ia rats fed a cholester01-free diet for 5 weeks were significantly decreased from 119•} 7.6mg/dl and 218•}39.0mg/dl to 94.2•}6.0mg/dl and 145•}20.0mg/dl, respectively, following sup plementation of 10% PF-C; 2) When rats on a standard diet were supplied with tap-water admixed with 20% PF and 5-20% PF-C against a control for 5 weeks, serum and liver cholesterol levels were significantly decreased according to the magnitude of the change in dietary fiber content; 3) Total bile acid excretion in feces was significanly increased in both the PF and PF-C groups; 4) The content of total short-chain fatty acids, especially propionic acid, in fecal volume rose significantly in both the PF and PF-C groups; 5) Confirmation of the effect of PF-C on serum and liver cholesterol levels was made by switching the drinking water from ordinary tap-water to the PF-C solution. Key Words indigestible dextrin, dietary fiber, lipid metabolism, lowering cholesterol, short chain fatty acid. (Received April 10, 1991) •H•¨'@ˆÛ‚ª•®'° •ì-p ‚ð‚Í ‚ ¶‚ß,'Ï "oe"\‰ü'P•ì-p‚âOEOE•´ ƒRƒOEƒXƒe ƒ••[ƒ‹'ቺ •ì-p"™,Ží •X• ¶'Ì‹@"\'²•ß•ì-p‚ð-L ‚· ‚邱‚AE‚Í ‚ae ‚-'m ‚ç‚ê ‚Ä‚¢‚é1)•`3)•B ‚µ‚© ‚µ‚È‚ª ‚ç,•H •¨ '@ˆÛ ‚ÌŽí-Þ‚Í'½ ‚-,‹N OE¹ ‚É ‚ae‚Á‚Ä•¨-•‰»Šw"I•«Ž¿‚ÍˆÙ‚È ‚é ‚±‚AE‚© ‚ç,"-OE»‚· ‚é• ¶-••ì-p ‚ÌŽí-Þ‚âOEø‰Ê ‚͈ê‚͈ê-l ‚Å ‚È‚¢•B ‚Ü‚½,OE¤ ‹ †ŽÒ ‚É ‚ae‚Á‚Ä'Î •Û‚âŽÀOE±•ð OE•‚ªˆÙ‚È ‚Á‚Ä ‚¢ ‚邽‚ß,ˆê-¥ ‚ÉOEø‰Ê ‚Ì‹-Žã‚ð"äŠr‚· ‚邱‚AE‚à•¢"ï‚Å‚ ‚é•B ‚±‚ê‚Ü‚Å,•H •¨'@ˆÛ ‚ÌŽ‰Ž¿ 'ãŽÓ ‰ü'P•ì-p ‚ɂ‚¢‚Ä‚ÌŽÀ OE± "IOE¤‹ †‚Ì'½ ‚-‚Í,ƒ‰ ƒb ƒg‚É ƒRƒOEƒX ƒeƒ••[ ƒ‹‚¨‚ae‚у‹‚¨‚ae‚Ñ'_•` Ž_ ‚ð•‰‰× ‚µ‚½‰h-{'g•¬ ‚Ì-¾Šm ‚È• ‡•¬ Ž"-¿‚ð-^‚¦,OEOE •´‚¨ ‚ae‚ÑŠÌ'ŸŽ‰Ž¿ ‚̕㕸-}• §‚ðŠÏŽ@‚· ‚邱‚AE‚É ‚ae ‚èOEŸ"¢ ‚³‚ê ‚Ä ‚«‚½4)5)•B‚µ‚© ‚µ,•Å ‹ß-L'Ë ‚ç‚Í "ú•í‚Ì•H• ¶Šˆ‚É‚¨‚¢¶Šˆ‚É‚¨¶Šˆ‚É‚¨‚¢ ‚Ä'_•`Ž_‚ð•ÛŽae‚· ‚é‹@‰ï‚Í‚Ù ‚AE‚ñ ‚Ç‚È‚¢ ‚±‚AE,‚Ü ‚½ ƒR ƒOE ƒXƒeƒ••[ƒ‹‚ɂ‚¢‚Ä‚Í"äŠr"I"÷-Ê‚Å‚ ‚邱‚AE‚È ‚Ç‚ð•l-¶ ‚µ‚Ä,‚± ‚ê ‚ç‚ðŠÜ ‚Ü‚È‚¢Ž"-¿•ðOE•‰º‚Å•H•¨'@ˆÛ ‚ÌŽ‰Ž¿'ã ŽÓ ‚É‹y‚Ú‚·‰e‹¿ ‚ðOEŸ"¢‚· ‚邱‚AE‚Ì-L ˆÓ •« ‚ð •à ‚¢ ‚Ä ‚¢ ‚é6)•B‚» ‚±‚Å,'˜ ŽÒ ‚ç‚Í"n-é•' ƒfƒ"ƒvƒ"‚ð"M •ª‰ðOEã,•ª ‰ae •E•¸•» ‚µ‚Ä'²•» ‚µ‚½•…-n•«•H•¨'@ˆÛ("ï •Á‰»•« ƒfƒLƒX ƒgƒŠƒ")‚Ì Ž‰Ž¿'ãŽÓ‚É‹y‚Ú‚·‰e‹¿‚ðOEŸ"¢‚· ‚é‚É•Û ‚µ‚Ä, ‚Ü‚¸in vitro‚Å"oeŽ¿•Á‰»•y 'f‚É 'Î ‚· ‚é'ï•R•«("ï •Á‰» •«)‚ð OEŸ"¢ ‚µ,ŽŸ ‚¢‚Å-L'Ë ‚炪•ñ•• ‚µ‚½ ƒR ƒOE ƒX ƒe ƒ••[ ƒ‹ •E'_•`Ž_-³"Y‰ÁŽ"-¿•ðOE•‚ÅOEø‰Ê(Ž‰ Ž¿'ãŽÓ‰ü 'P•ì-p) ‚ÌOEŸ•Ø‚ð•s ‚Á‚½•B ‚³ ‚ç‚É,ƒq ƒg‚Ì•HŽ-‚AE‰h-{'g•¬ ‚ª‹ß Ž-‚µ * • §664ˆÉ§664ˆÉ 'O Žs-k ˆÉ 'O 5-3 ** • §663 •¼ ‹{ Žs •• OEÉ •ì '¬ 1-1