The importance of animal models in the development of vaccines

15Citations
Citations of this article
74Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Efficient translation of basic vaccine research into clinical therapies greatly depends upon the availability of appropriate animal models. Testing novel vaccine candidates in animal models is a critical step in the development of modern vaccines. Animal models are being used to assess the quality and quantity of the immune response, to identify the optimal route of delivery and formulation, to determine protection from infection and disease transmission, and to evaluate the safety and toxicity of the vaccine formulation. Animal models help to make the translation from basic research to clinical application, and they often allow prediction of the vaccine potential, which helps in predicting the financial risks for vaccine manufacturers. Choosing an appropriate animal model has become increasingly important for the field, as each model has its own advantages and disadvantages. In this review, the criteria for selecting the right animal model, the advantages and disadvantages of various animal models, as well as the future needs for animal models are being discussed.

Cite

CITATION STYLE

APA

Kiros, T. G., Levast, B., Auray, G., Strom, S., Van Kessel, J., & Gerdts, V. (2012). The importance of animal models in the development of vaccines. In Innovation in Vaccinology: From Design, Through to Delivery and Testing (Vol. 9789400745438, pp. 251–264). Springer Netherlands. https://doi.org/10.1007/978-94-007-4543-8_11

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free