An overview of methods used in neurogenomics and their applications

Abstract

This chapter is an introduction to and an overview of neurogenomics-an analysis of genes in the nervous system and their application for diagnosis as well as potential therapeutics of disorders of the nervous system. The most important technologies are those for sequencing. Traditional as well as new techniques are described briefly including next-generation sequencing. Important applications include discovery of genomic biomarkers, brain mapping as well as connectomics, molecular diagnostics, drug discovery, and potential new therapeutics for neurologic disorders. Knowledge of the genes relevant to the nervous system will improve gene therapies and RNA interference approaches for neurologic disorders. Overall it will contribute to development of personalized neurology.