IL-17 in primary knee osteoarthritis and its relation with severity of the disease

Abstract

Objective: Is to measure serum level of interleukin 17 and correlate its level with disease severity in patients with primary knee OA. Methods: Serum was collected from patients with primary knee osteoarthritis and age- and sex-matched healthy control subjects. IL-17 was quantified by enzyme-linked immunosorbent assay. Osteoarthritis severity and grade were assessed using the Lequesne index and Kellgren and Lawrence (KL) grading system, respectively. Results: Serum IL-17 concentrations are significantly higher in patients (1039.5 pg/ml) than in controls (55 pg/ml) with p value<0.001. This is significantly positively correlated with degree of WOMAC, pain scale, Lequesne index, KL grade and with MRI grades. Conclusions: According to the results of the present study we can conclude that there is a strong relation between serum level of IL-17 and primary knee osteoarthritis and this may reflect the degree of severity of the disease to some extent