Sperm DNA Tests Are Clinically Useful: Pro

Abstract

The impact of sperm DNA fragmentation on male infertility and assisted reproductive treatment (ART) outcomes is one of the most frequently debated topics in reproductive medicine. Sperm DNA fragmentation testing has been performed for the past 30 years, and the existing literature reporting the benefits of sperm DNA tests remains unclear. In this chapter, we perform comprehensive meta-analyses and systematic reviews from the existing literature and summarize the impact of sperm DNA fragmentation on male reproductive health. In addition, we report the clinical value of sperm DNA testing and its benefits for couples undergoing ARTs. We also have identified critical aspects of sperm DNA testing that reduce the potential impact of DNA fragmentation on ART outcomes. Based on the evidence presented here and meta-analyses presented elsewhere, we conclude that sperm DNA damage is associated with a low male reproductive potential and testing is recommended for patients undergoing assisted treatment.