How to Manage Drug Interactions in Clinical Settings (1)

Abstract

The first academic subcommittee of the Japanese Society of Pharmaceutical Health Care and Sciences has a plan to create a guide on how to manage drug interactions in clinical settings. This review describes the information that forms the basis of the guide. This article, part (1), reports the results of a questionnaire on the content of the guide and also describes how to evaluate and manage drug interactions in clinical settings. The contents of the Drug Interaction Guideline for Drug Development and Labeling Recommendations, the new Japanese guideline, are also described. It is important also in clinical practice to appropriately evaluate and manage drug interactions based on a sufficient understanding of the new guideline and related information. 緒 言 医薬品開発過程における薬物相互作用の検討方 法および情報提供に関して，欧米に引き続いて日 本でも平成 26 年 7 月に厚生労働省より「医薬品 開発と適正な情報提供のための薬物相互作用ガイ ドライン（最終案） 」が発表され，さらに平成 29 年 9 月の改訂版の発表を経て平成 30 年 7 月 23 日