We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.
CITATION STYLE
Yan, H., Dobbie, Z., Gruber, S. B., Markowitz, S., Romans, K., Giardiello, F. M., … Vogelstein, B. (2002). Small changes in expression affect predisposition to tumorigenesis. Nature Genetics, 30(1), 25–26. https://doi.org/10.1038/ng799
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