G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies

3Citations
Citations of this article
11Readers
Mendeley users who have this article in their library.

Abstract

G-quadruplexes are emerging targets in cancer research and understanding how diagnostic probes bind to DNA G-quadruplexes in solution is critical to the development of new molecular tools. In this study the binding of an enantiopure NIR emitting [Os(TAP)2(dppz)]2+ complex to different G-quadruplex structures formed by human telomer (hTel) and cMYC sequences in solution is reported. The combination of NMR and time-resolved infrared spectroscopic techniques reveals the sensitivity of the emission response to subtle changes in the binding environment of the complex. Similar behaviour is also observed for the related complex [Os(TAP)2(dppp2)]2+ upon quadruplex binding.

References Powered by Scopus

Voltammetric Studies of the Interaction of Metal Chelates with DNA. 2. Tris-Chelated Complexes of Cobalt(III) and Iron(II) with 1, 10-Phenanthroline and 2, 2'-Bipyridine

1700Citations
N/AReaders
Get full text

High-throughput sequencing of DNA G-quadruplex structures in the human genome

910Citations
N/AReaders
Get full text

The regulation and functions of DNA and RNA G-quadruplexes

797Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Good Vibrations Report on the DNA Quadruplex Binding of an Excited State Amplified Ruthenium Polypyridyl IR Probe

5Citations
N/AReaders
Get full text

Role of Secondary Structure and Time-Dependent Binding on Disruption of Phthalocyanine Aggregates by Guanine-Rich Nucleic Acids

0Citations
N/AReaders
Get full text

NMR of proteins and nucleic acids

0Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Peterková, K., Stitch, M., Boota, R. Z., Scattergood, P. A., Elliott, P. I. P., Towrie, M., … Quinn, S. J. (2023). G-Quadruplex Binding of an NIR Emitting Osmium Polypyridyl Probe Revealed by Solution NMR and Time-Resolved Infrared Studies. Chemistry - A European Journal, 29(11). https://doi.org/10.1002/chem.202203250

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 5

71%

Professor / Associate Prof. 1

14%

Researcher 1

14%

Readers' Discipline

Tooltip

Chemistry 6

60%

Biochemistry, Genetics and Molecular Bi... 4

40%

Save time finding and organizing research with Mendeley

Sign up for free