The ability of a platelet-activating factor (PAF) antagonist to reduce infarct size has been reported in a animal model of focal brain ischemia. The authors studied the effect of PAF antagonist (TCV-309) on cold brain injury in rats. Twenty-four hours after injury, water content was determined by both drying-weighing and specific gravimetric techniques, and ischemic brain damage was assessed with 2,3,5-triphenyltetrazolium chloride in multiple coronal sections. Pretreatment with TCV-309 (lmg/kg) significantly reduced the water content (p < 0.01) and volume of ischemic damage (p < 0.001) produced by the cold brain injury. These results indicate that PAF antagonist can ameliorate secondary brain tissue damage following brain injury.
CITATION STYLE
Tokutomi, T., Sigemori, M., Kikuchi, T., & Hirohata, M. (1994). Effect of platelet-activating factor antagonist on brain injury in rats. Acta Neurochirurgica. Supplementum, 60, 508–510. https://doi.org/10.1007/978-3-7091-9334-1_139
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