Bacterial Surface Components as Immunomodulators

Abstract

Synthetically prepared derivatives of the cell wall of Gram-negative bacteria were tested for their immunomodulatory properties in mice Besides being able to activate splenic B cells polyclonally, as demonstrated by measuring the in incorporation [3H] thymadine into I DNA they could be shown to act as irnmunoadjuvants increasing the anti-SRBC arid the anti -DNP -BSA immune responses, to enhance the vaccine effect of Salmonella vaccines. and to induce tumor cytotoxicity city in bone lie marrow-derived culture macrophages pH ages The results show to that such derivatives of the bacterial cell wall constitute patent immunomodulators in vitro and in vivo