Traditional biomarkers in narcolepsy: Experience of a Brazilian sleep centre

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Abstract

This study was thought to characterized clinical and laboratory findings of a narcoleptic patients in an out patients unit at São Paulo, Brazil. Method: 28 patients underwent polysomnographic recordings (PSG) and Multiple Sleep Latency Test (MSLT) were analyzed according to standard criteria. The analysis of HLADQB1*0602 allele was performed by PCR. The Hypocretin-1 in cerebral spinal fluid (CSF) was measured using radioimmunoassay. Patients were divided in two groups according Hypocretin-1 level: Normal (N) - Hypocretin-1 higher than 110pg/ml and Lower (L) Hypocretin-1 lower than 110 pg/ml. Results: Only 4 patients of the N group had cataplexy when compared with 14 members of the L group (p=0.0002). Discussion: This results were comparable with other authors, confirming the utility of using specific biomarkers (HLA-DQB1*0602 allele and Hypocretin-1 CSF level) in narcolepsy with cataplexy. However, the HLADQB1*0602 allele and Hypocretin-1 level are insufficient to diagnose of narcolepsy without cataplexy.

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Coelho, F. M. S., Pradella-Hallinan, M., Pedrazzoli, M., Soares, C. A. S., Fernandes, G. B. P., Goņalves, A. L., … Bittencourt, L. R. A. (2010). Traditional biomarkers in narcolepsy: Experience of a Brazilian sleep centre. Arquivos de Neuro-Psiquiatria, 68(5), 712–715. https://doi.org/10.1590/S0004-282X2010000500007

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