Health-related quality of life and depression in Rett syndrome caregivers

Abstract

Background/Aim. Rett syndrome (RTT) is a severe neurodevelopmental disorder primarily affecting females with an estimated incidence of 1 : 10,000-15,000 female births. Currently, there is no specific treatment that halts or reverses the progression of RTT. Therefore, management was mainly symptomatic, focussed on optimising patient's abilities. The aim of this study was to investigate factors influencing health-related quality of life (HRQoL) and depression in mothers who care for children with Rett syndrome (RTT) in Serbia. Methods. The cross-sectional study was conducted on 49 mothers giving care to females with RTT. Caregivers` HRQoL was assessed by using the SF-36 questionnaire. Clinical severity score (CSS) of RTT patients and Beck Depression Inventory II (BDI -II) scale were used to quantify RTT severity and mothers` depression, respectively. Statistical assessment included descriptive statistics, ttest, Pearson correlation coefficient and multiple logistic regression. Results. The age of mothers ranged from 22 to 55 years and of their affected children from 3 to 29 years. Severe depression was observed in 15 (30.6%) participants. CSS and BDI - II scores correlated negatively with all SF- 36 domains and composite scores. Lowest scoring domains of HRQoL in mothers giving care to RTT children were mental health, vitality and role functioning emotional. Multiple linear regression analysis revealed that severity of RTT patients` disability (CSS) and caregivers` age are factors with strongest influence to HRQoL and depression in care giving mothers. Conclusion. Mothers giving care to children with RTT are at high risk of severe depression and lower HRQoL scores of domains that reflect mental well-being. Results of this study can help in planning subsequent interventions directed at families dealing with Rett syndrome.Uvod/Cilj. Retov sindrom (RTT) je tezak neurorazvojni poremecaj koji prvenstveno pogadja devojcice. Incidencija se procenjuje na 1 : 10 000-15 000 zivorodjene dece zenskog pola. Trenutno ne postoji specificna terapija koja bi mogla da promeni tok ove bolesti. Stoga je tretman uglavnom simptomatski sa naglaskom na unapredjenje pojedinih sposobnosti bolesnika. Cilj ove studije bio je ispitivanje faktora koji uticu na kvalitet zivota (HRQoL) i depresiju majki koje brinu o deci oboleloj od RTT u Srbiji. Metode. Studija preseka je obuhvatila 49 majki koje brinu o deci oboleloj od RTT. Kvalitet zivota je ispitivan pomocu SF- 36 upitnika. Skor tezine klinicke slike (CSS) bolesnika sa RTT i Bekova skala depresije II (BDI - II) upotrebljeni su u proceni tezine bolesti kod dece, odnosno stepena depresije kod majki. Statisticka analiza je ukljucila deskriptivne metode, t-test, Pirsonov koeficijent korelacije i multiplu linearnu regresiju. Rezultati. Starost majki kretala se u rasponu od 22 do 55 godina, a uzrast bolesnika od 3 do 29 godina. Teska depresija je zapazena kod 15 (30,6%) ucesnica u studiji. Skorovi CSS i BDI - II negativno su korelisali sa svim SF-36 dimenzijama i zbirnim skorovima. Najnize ocenjene dimenzije kvaliteta zivota kod majki koje brinu o deci sa Retovim sindromom su mentalno zdravlje, vitalnost i emocionalno funkcionisanje. Multipla linearna regresija pokazala je da godine majke i tezina klinicke slike deteta imaju najsnaznije dejstvo u pravcu pojave depresije i losijeg kvaliteta zivota u ovoj populaciji. Zakljucak. Majke koje brinu o deci sa RTT imaju visok rizik za pojavu teske depresije i nizih skorova HRQoL u domenima koji odrazavaju mentalno stanje. Rezultati ove studije mogu pomoci u planiranju adekvatne podrske porodicama koje imaju clanove obolele od RTT.