Abstract
An estimated 8,490 Americans were diagnosed as having Hodgkin lymphoma (HL) in 2010 [1]. HL is a B-cell lymphoma that arises from germinal center or post-germinal center B cells. Two types of classic HL (cHL) make up 95 % of HL diagnoses; in contrast, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is rare and has distinct pathologic features. cHL is unique in that the CD30-positive Reed-Sternberg (RS) cells often make up less than 1 % of the tumor and are surrounded by a rich microenvironment, including CD20-positive reactive B cells that are believed to provide survival signals to the RS cells.
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CITATION STYLE
Fanale, M., Dabaja, B., Popat, U., Anderlini, P., & Younes, A. (2012). Hodgkin lymphoma. In 60 Years of Survival Outcomes at the University of Texas MD Anderson Cancer Center (pp. 225–239). Springer New York. https://doi.org/10.1007/978-1-4614-5197-6_21
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