Beta1,3-NAcetylgalactosaminyltransferase 2 (B3GALNT2)

Abstract

Tηε β1,3-glycosyltransferases (β3GT) family consists of β1,3-galactosyltransferases (B3GALT), β1,3-N-acetylglucosaminyltransferases (B3GNT), and β1,3-N-acetylgalactosaminyltransferase (B3GALNT). Based on a comparison of the sequences of four β3GALT, three conserved sequences (β3GT motifs) were found in the catalytic domain of the β3GT family except for B3GNT1 (Isshiki et al. 1999). Three β3GT motifs are (I/L)RxxWG, (F/Y)(V/L/M)xxxDXD, and (E/D)D(A/V)(Y/F)xGx(C/S) found in more than 20 β3GT genes (Narimatsu 2006; Togayachi et al. 2006). By a BLAST search using the β3GT motifs, a human B3GALNT2 cDNA encoding 500 amino acids was identified and cloned (Hiruma et al. 2004).