Necroptosis is a caspase-independent form of programmed cell death that is induced by a variety of different signalling cascades—all culminating in the activation of the pseudokinase mixed lineage kinase domain-like (MLKL). TNF-induced necroptosis is the most intensively studied of these pathways. Here we describe reagents and cell-based techniques that can be used to investigate TNF-mediated necroptosis in the lab.
CITATION STYLE
Liu, Z., Silke, J., & Hildebrand, J. M. (2018). Methods for studying TNF-mediated necroptosis in cultured cells. In Methods in Molecular Biology (Vol. 1857, pp. 53–61). Humana Press Inc. https://doi.org/10.1007/978-1-4939-8754-2_5
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