Are you interested or afraid of working on EMT?

Abstract

When referring to the epithelial-to-mesenchymal transition (EMT), readers are familiar with sentences alluding to its pivotal role both in embryonic development and in disease. Following that argument, usually there is a point on the importance of studying the process and the impact it has on the design of therapeutic strategies. However, it is also very common to find arguments on how the EMT is very difficult to tackle, being a somehow obscure and complex process, where the field cannot reach universal conclusions, particularly in pathological contexts. Even worse, it is sometimes defined as a process that cannot be described with universal markers, making it therefore very difficult for cancer studies, where there is a need to use optimal animal models and stratify patients for differential therapeutic strategies. In the face of all this, the question is whether you have been frightened off working on pathological EMTs, or even if you are not interested anymore and would prefer waiting till the field reaches a steady state of robust knowledge. Do not be afraid and be interested now. It only involves being more plastic, like the EMT itself.