AFMR Southern Regional Meeting Abstracts

Abstract

Cardiovascular Club: Mentored Oral Presentation 11:00 AM Thursday, February 21, 2008 ### 1 THE PREDICTIVE VALUE OF LEFT ATRIAL SIZE FOR INCIDENT ISCHEMIC STROKE AND ALL-CAUSE MORTALITY IN AFRICAN AMERICANS: THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC)STUDY H.S. Nagarajarao, A.D. Penman, H.A. Taylor, T. Mosley, K. Butler, T. Skelton, T. Samdarchi, and E.R. Fox. University of Mississippi Medical Center, Jackson, MS. #### Purpose of Study The association between left atrial (LA) size, ischemic stroke and death has been investigated in non-Hispanic whites but not in African Americans despite their disproportionately higher rates of stroke and cardiovascular mortality. #### Methods Used Participants in the Jackson cohort of the Atherosclerosis Risk in Communities study have had extensive baseline evaluations, echocardiograms during the third examination (1993-1995), and have been followed for incident ischemic stroke and all-cause mortality. #### Summary of Results Of total 1887 participants 65% were women and had a mean age ± SD of 58.9 ± 5.7 years. LA diameter by tertile was significantly related to hypertension, diabetes and body mass index (BMI) (p<0.0001 for each). Over a median follow-up of 8.8 years for ischemic stroke and 8.9 years for all-cause mortality, there were a total of 103 strokes (6.47 per 1,000 person-years) and 206 deaths (13.3 per 1,000 person-years). After adjusting for age, sex, cigarette smoking, diabetes, hypertension, BMI, total cholesterol: HDL ratio, and triglycerides in a multivariable model, LA size was significantly related to ischemic stroke and all-cause mortality (hazard ratio (HR) 1.58; 95% CI: 1.09, 2.29, p=0.02 and HR 1.47; 95% CI: 1.13, 1.91, p=0.004 respectively). After further adjustment for left ventricular hypertrophy (LV) hypertrophy. LA size remained significantly related to all-cause mortality (HR 1.40; 95% CI: 1.07, 1.82, p=0.01). #### Conclusions In this population based cohort of African Americans echocardiographic LA size was significantly associated with all-cause mortality after adjusting for traditional cardiovascular risk factors and echocardiographic LV hypertrophy. ### 2 OBESITY IS THE MAJOR PREDICTOR FOR DEVELOPMENT OF LEFT VENTRICULAR REMODELING IN YOUNG ADULTS: BOGALUSA HEART STUDY A. Toprak, H. Wang, S. Srinivasan, W. Chen, T. Paul, and G. Berenson. Tulane Center for Cardiovascular Health, New Orleans, LA. #### Purpose of Study Left ventricular structural alterations are associated …