Hyosgerin, a new optically active coumarinolignan, from the seeds of Hyoscyamus niger

Abstract

Hyosgerin, a new optically active coumarinolignan, has been isolated and characterized along with three other coumarinolignans, venkatasin, cleomiscosin A and cleomiscosin B, from the seeds of Hyoscyamus niger L. The structure was determined on the basis of spectroscopic analysis and chemical conversion. The optical properties and absolute stereochemistry of these coumarinolignans have also been studied and discussed. © 2006 Pharmaceutical Society of Japan.