Differential gene expression in HIV/SIV-associated and spontaneous lymphomas

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Abstract

Diffuse large B-cell lymphoma (DLBCL) is more prevalent and more often fatal in HIV-infected patients and SIV-infected monkeys compared to immune-competent individuals. Molecular, biological, and immunological data indicate that virus-associated lymphomagenesis is similar in both infected hosts. To find genes specifically overexpressed in HIV/SIV-associated and non-HIV/SIV-associated DLBCL we compared gene expression profiles of HIV/SIV-related and non-HIV-related lymphomas using subtractive hybridization and Northern blot analysis. Our experimental approach allowed us to detect two genes (a-myb and pub) upregulated solely in HIV/SIV-associated DLBCLs potentially involved in virus-specific lymphomagenesis in human and monkey. Downregulation of the pub gene was observed in all non-HIV-associated lymphomas investigated. In addition, we have found genes upregulated in both non-HIV- and HIV-associated lymphomas. Among those were genes both with known (set, ND4, SMG-1) and unknown functions. In summary, we have demonstrated that simultaneous transcriptional upregulation of at least two genes (a-myb and pub) was specific for AIDS-associated lymphomas. Copyright© Ivyspring International Publisher.

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Nenasheva, V. V., Nikolaev, A. I., Martynenko, A. V., Kaplanskaya, I. B., Bodemer, W., Hunsmann, G., & Tarantul, V. Z. (2005). Differential gene expression in HIV/SIV-associated and spontaneous lymphomas. International Journal of Medical Sciences, 2(4), 122–128. https://doi.org/10.7150/ijms.2.122

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