Liver lysosomal enzymes during macrophage depression (gadolinium chloride, 7 mg/kg, intravenously) and macrophage stimulation (zymosan, 100 mg/kg, intravenously) have been studied. It was shown that gadolinium chloride treatment of rats reduced the rate of carbon particles phagocytosis at 24 and 48 h after the single administration. Decreased endocytic capacity of Kupffer cells was confirmed also by electron microscopy. Gadolinium chloride induced labilization of liver lysosomes (increased free activity of cathepsins B and L); there was no changes of specific activity of liver cysteine proteinases (24 h). Gadolinium chloride prevented death of rats after administration of non-sonicated particular zymosan particles, resulting to 70% survival, compare with the 17% survival in group zymosan alone. We can summarize that macrophages depression by gadolinium chloride abolish symptoms of inflammation in zymosan-model, influencing of cysteine proteinases of Kupffer cells.
CITATION STYLE
Korolenko, T., Svechnikova, I., Urazgaliyev, K., Vakulin, G., & Djanaeva, S. (1997). Liver cysteine proteinases in macrophage depression induced by gadolinium chloride. Advances in Experimental Medicine and Biology, 421, 315–321. https://doi.org/10.1007/978-1-4757-9613-1_41
Mendeley helps you to discover research relevant for your work.