Synthesis, Characterization and Study of some of New Mefenamic Acid Derivatives as cytotoxic Agents

Abstract

A new system drugs derivative was designed from Mefenamic Acid. These derivatives have been synthesized by reaction between mefenamic acid and different amino drugs via amide group. A number of compounds based on this new scaffold were prepared in good yields. These compounds have been purified and followed using TLC to determine purity with Rf value. All synthesized compounds structures were confirmed by 1H-NMR, 13CNMR and FTIR techniques. All compounds were evaluated for their anticancer and anti-bacterial activities. Some of the compounds synthesized showed cytotoxic activities in vitro. Most of synthesized compounds induced significant reduction in the cytotoxic response as compared with controls.