Anomalia de pelger-huët - relato de caso

Abstract

Pelger-Huët anomaly is a rare hereditary disorder characterized by failure of the nucleus of granulocytes, especially neutrophils, to undergo normal maturation to the segmented form. Affected neutrophils have unsegmented or round nuclei, but chromatin condensation and cytoplasmic development resemble that of normal mature granulocytes. This nuclear hyposegmentation results in an apparent left shift in neutrophils. Affected animals have a normal total leukocyte count, but the major form of neutrophils is at the band stage, with bands comprising 30-70% of total cells. The Pelger-Huët anomaly has been reported in humans, rabbits, dogs, and cats. Few cases had been described in animals and, in the state of Espiríto Santo not yet had been reported. Recognition of this syndrome is important to prevent an incorrect association with diseases that produce a left shift. A case report of the Pelger-Huët anomaly is presented in a 9 years old Cocker Spaniel female dog.