Formulation and Evaluation of Oxcarbazepine Suspension: In vitro/In vivo Correlation

Abstract

Aims: Oxcarbazepine was formulated as suspension in order to perk up the palatability, augment bioavailability of the product, furthermore extended to estimate good degree of in vitro in vivo correlation (IVIVC). Methodology: Oxcarbazepine had poor aqueous solubility, thus the solubility was increased by hydrotropes then formulated into suspension using taragum as viscosity enhancer. Further validity of dissolution study was extended by In vitro/In vivo correlation using level A method. Results: These suspensions were observed for in vitro dissolution profile and studied for in vivo pharmacokinetic profile, from the obtained values, a level A IVIVC modeling was observed, interestingly from the results attained suspension showed almost 98% drug release (FDR) and 85% drug absorbed (FDA) in 90min. Fascinatingly, from the correlation between FDR and FDA, slope and regression coefficient obtained was near to 1.0