Electrical stimulation towards melanoma therapy via liquid metal printed electronics on skin

Abstract

Background: We proposed a method of using electrical stimulation for treatment of malignant melanoma through directly spray-printing liquid metal on skin as soft electrodes to deliver low intensity, intermediate frequency electric fields. Methods: With patterned conductive liquid metal components on mice skin and under assistance of a signal gen-erator, a sine wave electrical power with voltage of 5 V and 300 kHz could be administrated on treating malignant melanoma tumor. Findings: The experiments demonstrated that tumor volume was significantly reduced compared with that of the control group. Under the designed parameters (signal: sine wave, signal amplitude Vpp: 5 V and Vpp: 4 V, frequency: 300 kHz) of Tumor treating fields (TTFields) with the sprayed liquid metal electrode, four mice tumor groups became diminishing after 1 week of treatment. The only device-related side effect as seen was a mild to moderate contact dermatitis underneath the field delivering electrodes. The SEM images and pathological analysis demonstrated the targeted treating behavior of the malignant melanoma tumor. Further, thermal infrared imaging experiments indicated that there occur no evident heating effects in the course of treatment. Besides, the liquid metal is easy to remove through medical alcohol. Conclusions: Tumor treating fields through liquid metal electrode could offer a safe, straightforward and effective treatment modality which evidently slows down tumor growth in vivo. These promising results also raised the pos-sibility of applying spray-printing TTFields as an easy going physical way for future cancer therapy.