Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma

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Abstract

Interleukin 12 (IL-12) is a major inducer of interferon gamma (IFN-γ) and the principal mediator of T helper 1 (Th1) differentiation. To identify IL-12-regulated genes, which might contribute to Th1 differentiation and IFNG regulation, we employed microarray analysis. Surprisingly, a ubiquitously expressed proprotein convertase (PC), furin, was one of the most consistently IL-12-induced genes in T cells, and among PCs was the only one regulated by this cytokine. Furin was preferentially expressed in differentiated Th1 cells in a Stat4-dependent manner. Expression of furin enhanced IFN-γ secretion, whereas inhibition of furin interfered with IFN-γ production. Thus, we conclude that IL-12 induction of furin might represent a new aspect of IFN-γ regulation and control of Th1 differentiation. © 2006 by The American Society of Hematology.

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Pesu, M., Muul, L., Kanno, Y., & O’Shea, J. J. (2006). Proprotein convertase furin is preferentially expressed in T helper 1 cells and regulates interferon gamma. Blood, 108(3), 983–985. https://doi.org/10.1182/blood-2005-09-3824

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