Dielectric Properties of Porcine Brain Tissue in the Transition from Life to Death at Frequencies from 800 to 1900 MHz

Abstract

Ten experiments on pigs were performed to investigate possible postmortem changes of the dielectric properties of brain gray matter in the frequency range of 800-1900 MHz. After keeping the animals in stable anaesthesia for at least 45 min, they were euthanatised by an intravenous injection of hypertonic potassium chloride (KCl), causing cardiac arrest within 3 min. Measurements of the dielectric properties were performed repeatedly from at least 45 min prior to death to 18 h after euthanasia. The anaesthesia regimen was chosen to minimize influence on brain tissue characteristics such as brain water content, intracranial blood volume, and cerebral blood flow. The data showed a decline of mean gray matter equivalent conductivity of about 15% at 900 MHz and about 11% at 1800 MHz within the first hour after death. The decline in permittivity was less pronounced (about 3-4%) and almost frequency independent. The results indicate that in vitro measurements of dielectric properties of brain tissue underestimate equivalent conductivity as well as permittivity of living tissue. These changes may affect the generally accepted data of dielectric properties of brain tissue widely used in RF dosimetry. © 2003 Wiley-Liss, Inc.