There is a long list of important RNA-binding proteins (RBP) involved in different steps of gene expression through posttranscriptional modifications: pre-mRNA splicing, mRNA stabilization, polyadenylation, mRNA export from nucleus to the cytoplasm, and translation. The critical role of RNA–protein interaction necessitates a continuous identification of proteins involved in this process. Here we describe the identification of Poly-ADP-Ribose Polymerase 1 (PARP1) as an RNA binding protein involved in RNA splicing.
CITATION STYLE
Mekishvili, M., Matveeva, E., & Fondufe-Mittendorf, Y. (2017). Methodology to identify poly-ADP-ribose polymerase 1 (PARP1)–mRNA targets by PAR-CLiP. In Methods in Molecular Biology (Vol. 1608, pp. 211–228). Humana Press Inc. https://doi.org/10.1007/978-1-4939-6993-7_15
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