The adaptive immune system - with its remarkable ability to generate antigen-specific antibodies and T lymphocytes against pathogens never before "seen" by an organism - is one of the marvels of evolution. However, to generate these responses, the adaptive immune system requires activation by the innate immune system. Toll-like receptors (TLRs) are perhaps the best-understood family of innate immune receptors for detecting infections and stimulating adaptive immune responses. TLR9 appears to have evolved to recognize infections by a subtle structural difference between eukaryotic and prokaryotic/viral DNA; only the former frequently methylates CpG dinucleotides. Used as vaccine adjuvants, synthetic oligodeoxynucleotide (ODN) ligands for TLR9 - CpG ODN - greatly enhance the speed and strength of the immune responses to vaccination. © Springer-Verlag 2006.
CITATION STYLE
McCluskie, M. J., & Krieg, A. M. (2006). Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA. Current Topics in Microbiology and Immunology. Springer Verlag. https://doi.org/10.1007/3-540-32636-7_6
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